primary antibodies against human abca12 (GeneTex)
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Primary Antibodies Against Human Abca12, supplied by GeneTex, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 90 stars, based on 1 article reviews
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1) Product Images from "Regional Differences in the Permeability Barrier of the Skin—Implications in Acantholytic Skin Diseases"
Article Title: Regional Differences in the Permeability Barrier of the Skin—Implications in Acantholytic Skin Diseases
Journal: International Journal of Molecular Sciences
doi: 10.3390/ijms221910428
Figure Legend Snippet: Different barrier functions and gene expression profiles of permeability barrier components characterize healthy GP, AGR, and SGR skin regions. ( a ) Transepidermal water loss levels in healthy GP, AGR, and SGR skin areas. Measurements were carried out with Tewameter TM300 (Courage and Khazaka, Cologne, Germany) on the flexural forearm, axilla, and forehead of healthy individuals ( n = 30). Gene expression of the components of ( b ) cornified envelope formation, ( c ) corneocyte desquamation, ( d ) intercellular lipid lamellae, ( e ) desmosome organization, and ( f ) tight junction formation in healthy GP, AGR, and SGR skin regions were examined by qRT-PCR. The graphs show the mean ± 95% confidence interval of measured mRNA transcript levels (* p < 0.05, ** p < 0.01, *** p < 0.001, determined by one-way ANOVA followed by Sidac post hoc test). Abbreviations: ABCA12, ABC transporter 12B; AGR, apocrine gland-rich; CDH, cadherin; CDSN, corneodesmosin; CLDN, claudin; DSC, desmocollin; DSG, desmoglein; GP, gland-poor; KLK, kallikrein-related peptidase; KRT, keratin; LCE, late cornified envelope; OCLN, occludin; PKP, plakophilin; SGR, sebaceous gland-rich; SPRR, small proline-rich protein; TEWL, transepidermal water loss; TGM, transglutaminase.
Techniques Used: Gene Expression, Permeability, Quantitative RT-PCR
Figure Legend Snippet: Prominently weakened cell junction components characterize SGR and AGR skin regions compared with GP areas under steady-state. Representative images for immunostaining and quantification of epidermal levels of KRT1, TGM5, CDSN, DSG1, CLDN1, OCLN, ABCA12, KLK5, and KLK7 in healthy GP, AGR, and SGR skin sections. Bar = 100 μm. Means ± 95% confidence intervals for protein levels are shown. (* p < 0.05, ** p < 0.01, *** p < 0.001, determined by one-way ANOVA followed by Sidac post hoc test) Abbreviations: ABCA12, ABC transporter 12B; AGR, apocrine gland-rich; CDSN, corneodesmosin; CLDN, claudin; DSG1, desmoglein 1; GP, gland-poor; KLK, kallikrein-related peptidase; KRT, keratin; OCLN, occludin; SGR, sebaceous gland-rich; TGM, transglutaminase.
Techniques Used: Immunostaining